|
KMID : 1145520160020020123
|
|
Journal of Radiopharmaceuticals and Molecular Probes
2016 Volume.2 No. 2 p.123 ~ p.131
|
|
|
Consecutive automated production of carbon-11 labeled radiopharmaceuticals by sharing 11C-methylation reagent from one 11 C-synthetic module
|
|
Park Hyun-Sik
Lee Hong-Jin
An Hyun-Ho
Moon Byung-Seok
Lee Byung-Chul
Kim Sang-Eun
|
|
|
Abstract
|
|
|
Increasing clinical demand for carbon-11 labeled radiopharmaceuticals has triggered technological advances in fields of radiochemistry and automated modules. Even though carbon-11 has a short half-life (t1/2 = 20.4 min), the consecutive second production of carbon-11 labeled radiopharmaceutical in one 11C-synthetic module should be delayed at least over 4 h to avoid the high radiation exposure. We herein aimed to produce two different carbon-11 labeled radiopharmaceuticals ([11C]PIB and [11C]methionine) by sharing of [11C]methylation source in one 11C-synthetic module. The synthesis of 11C-labeling reagents ([11C]CH3I or [11C]CH3OTf) is fully automated using the commercial TRACERlab FXC-pro module and is readily adaptable to 11C-labeling reactor for [11C]PIB as well as another 11C-labeling apparatus for [11C]methionine via the three-way valve. After completing the [11C]PIB production, the re-synthesized [11C]CH3
I was passed through the three-way valve connected the polyetheretherketone (PEEK) line and loaded into the C18 Sep-Pak cartridge including the methionine precursor. The labeled product [11C]methionine was purified by a simple cartridge separation and reformulated into saline. The radiochemical yield of [11C]PIB and [11C]methionine were 5.3 ± 0.6% and 18.7 ± 0.8% (n.d.c.), respectively, with over 97% of radiochemical purity. The specific activity of [11C]PIB was over 110 GBq/μmol. Total production time of two radiopharmaceuticals needs about 2 h from 1st beam irradiation including quality control tests. Final [11C]PIB and [11C]methionine were satisfied all quality control test standards.
|
|
|
KEYWORD
|
|
|
[11C]Methionine, [11C]PIB, Automatic production, Radiopharmaceuticals
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|